The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
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The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
Imprint | Springer-Verlag |
Country of origin | Germany |
Series | Current Topics in Microbiology and Immunology, 373 |
Release date | November 2013 |
Availability | Expected to ship within 12 - 17 working days |
First published | 2014 |
Editors | Thomas Boehm, Yousuke Takahama |
Dimensions | 235 x 155 x 15mm (L x W x T) |
Format | Hardcover |
Pages | 132 |
Edition | 2014 ed. |
ISBN-13 | 978-3-642-40251-7 |
Barcode | 9783642402517 |
Categories | |
LSN | 3-642-40251-8 |