This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze this data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students.
Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as inference under order restrictions and non-linear parametric models, which are used in the second part of the book.
Part II is the core of the book, in which we focus on the analysis of dose-response microarray data. Methodological topics discussed include:
Multiplicity adjustment
Test statistics and procedures for the analysis of dose-response microarray data
Resampling-based inference and use of the SAM method for small-variance genes in the data
Identification and classification of dose-response curve shapes
Clustering of order-restricted (but not necessarily monotone) dose-response profiles
Gene set analysis to facilitate the interpretation of microarray results
Hierarchical Bayesian models and Bayesian variable selection
Non-linear models for dose-response microarray data
Multiple contrast tests
Multiple confidence intervals for selected parameters adjusted for the false coverage-statement rate
All methodological issues in the book are illustrated using real-world examples of dose-response microarray datasets from early drug development experiments.
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This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze this data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students.
Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as inference under order restrictions and non-linear parametric models, which are used in the second part of the book.
Part II is the core of the book, in which we focus on the analysis of dose-response microarray data. Methodological topics discussed include:
Multiplicity adjustment
Test statistics and procedures for the analysis of dose-response microarray data
Resampling-based inference and use of the SAM method for small-variance genes in the data
Identification and classification of dose-response curve shapes
Clustering of order-restricted (but not necessarily monotone) dose-response profiles
Gene set analysis to facilitate the interpretation of microarray results
Hierarchical Bayesian models and Bayesian variable selection
Non-linear models for dose-response microarray data
Multiple contrast tests
Multiple confidence intervals for selected parameters adjusted for the false coverage-statement rate
All methodological issues in the book are illustrated using real-world examples of dose-response microarray datasets from early drug development experiments.
"
Imprint | Springer-Verlag |
Country of origin | Germany |
Series | Use R! |
Release date | August 2012 |
Availability | Expected to ship within 10 - 15 working days |
First published | 2012 |
Editors | Dan Lin, Ziv Shkedy, Daniel Yekutieli, Dhammika Amaratunga, Luc Bijnens |
Dimensions | 235 x 155 x 16mm (L x W x T) |
Format | Paperback |
Pages | 282 |
Edition | 2012 |
ISBN-13 | 978-3-642-24006-5 |
Barcode | 9783642240065 |
Categories | |
LSN | 3-642-24006-2 |