Handbuch Der Experimentellen Pharmakologie -- Erganzungswerk - Funfter Band (German, Paperback, 1937 ed.)

195 in the coronary flow of the perfused cat's heart. KREITMAIR confirmed this action by a different method. Using heart-lung preparation in dogs with a MORAWITZ coronary canula, he found that harmol (10 mgm. per Kilo) produced 1 a remarkable increase in the coronary flow. BRAMWELL, CAMPBELL and EVANS treated 20 patients suffering from angina pectoris with propylharmol by mouth and found benefit from the drug in four early cases but no improvement in the more severe types. Seven out of 41 cases of angina, treated by harmol hydro chloride by mouth, appeared to be improved. Comparative Actions on the Uterus. The stimulant action on the uterus, first observed with harmaline, was investigated subsequently with other compounds with a view to determining QUi"i." l,""rl111Olol Quill;'''' QlIillillC IIarmnlol I mg per kilo. J mg per kilo. In/( per kilo. a mg per kilo. 0.3 mg /ler kilo. Fig.5. Rabbit, non.pregnant, anaesthetised by urethane; contractions of uterus recorded in situ; varying doses of harmalol and quinine intravenously. Showing that 0.3 mgm. per kgm, harmalol in about equnl, in activity on the uterus, to 5.0 mgm. quinine."